Tertiary Butyl Acetate has numerous industrial uses and is commonly used in adhesives, degreasers, and industrial coatings. The biological effects of tert-butyl acetate were studied in rats exposed to the compound for six hours. Exposure to the chemical resulted in partial saturation of the body tissues. Further studies were carried out to determine the toxicity of the compound. The safety of tert-butyl acetate can be determined by using OSHA method references.
In addition to causing eye irritation, Tertiary Butyl Acetate is also highly irritating to skin and respiratory organs. High concentrations of the chemical may have a CNS depressant effect. Symptoms of tert-butyl acetate include headaches, eye irritation, and respiratory discomfort. The chemical also gives off a pungent fume and can be irritating to the eyes. Despite being a volatile organic compound, Tertiary Butyl Acetate is a non-hazardous air pollutant and an excellent substitute for xylene, toluene, and ketones. It has also been used as a gasoline additive. In fact, tertiary butyl acetate has been used for more than a century, replacing many other hazardous solvents. This substance is inherently biodegradable. Its half-life is approximately 5 days. This makes it a relatively low risk for aquatic life. Its toxicity to humans and animals is unknown. Research has indicated that Tertiary Butyl Acetate may occur in the environment during photochemical oxidation of other chemicals. This chemical has been identified as a byproduct of gas-phase reactions of ethyl-n-butyl ether with hydroxyl radicals in the presence of nitric oxide. The molar yield of butyl acetate for the reaction with hydroxyl radicals was 0.032 +/- 0.001, while for the reactions with di-tert-butyl ether, the yield was 0.84 (+/-). The risks of exposure to tertiary butyl acetate and its isomers are unknown. In addition, there is little data on their toxicity in animals. Research on n-butyl acetate, its most common isomer, has limited data, and has not been tested in humans. Nevertheless, studies on tert-butyl acetate indicate that it may be dangerous to humans. In a simple distillation process, Tertiary Butyl Acetate is produced in a column that includes acetic acid. The distillation column transports this mixture downstream, which is referred to as the final step. It is highly purified. In addition, the product is a high-grade chemical. Acute exposure to Tertiary Butyl Acetate has been linked to a range of health effects. The lowest dose for human exposure has been measured at 0.4 mg/m3 after a 13-week study with rats. The tolerable exposure range for butyle acetate is 0.4 mg/m3, and the average exposure in homes and work sites is around 0.02 mg/m3. Its effects on olfaction have been studied in animals. When applied to the clipped dorsal skin of a New Zealand White rabbit, it causes erythema and oedema. The odor produced by this chemical is 6 times more potent than nasal pungency and eye irritation. Excessive exposure to it may lead to death in guinea pigs. One study found that lettuce was exposed to tertiary butyl acetate aerosols at different concentrations. The higher concentrations produced a shorter onset of symptoms, but the time course of clinical signs was similar. In addition, postmortem examination showed evidence of pulmonary congestion and haemorrhage. In the same way, tert-butyl acetate is much more dangerous than n-butyl acetate.
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