Pemphigus vulgaris is a chronic, severe autoimmune disorder that can be life-threatening. Depending on the severity of the disease, patients are often hospitalized. Moreover, it can have serious emotional effects on the patient. Therefore, it is important to educate patients about their condition and offer them close follow-up visits with specialists.
Pemphigus Vulgaris is an autoimmune disorder in which the immune system attacks healthy skin cells and causes erosions of the mucous membranes. Symptoms of PV include blisters and acantholysis. The disease is associated with complications that are severe and can affect patients' health-related quality of life. Pemphigus Vulgaris Treatment can be accomplished using a variety of drugs. The primary objectives are to control the disease and prevent relapses. Although the treatments are effective, there is still a need for improved treatment strategies. Some of the available therapies for pemphigus vulgaris include methotrexate, mycophenolate mofetil, cyclophosphamide, and immunoadsorption. Biological drugs may also be used. Systemic corticosteroids are considered the primary drug of choice for pemphigus vulgaris. They can help to reduce the severity of the condition and control the lesions, whereas they can also have serious adverse effects. They should be used carefully. Among the adverse effects, oral corticosteroids may cause stomach ulcers and infections. When used in severe cases, they can also lead to osteoporosis and diabetes mellitus. Pemphigus Vulgaris Treatment may be administered systemically or locally. Local measures may provide some relief from the symptoms of the disease, while systemic measures are intended to achieve complete remission. An interprofessional approach can optimize outcomes. One of the most promising approaches to Pemphigus Vulgaris Treatment is rituximab. Rituximab has been characterized as an effective corticosteroid-sparing agent and has shown good results as a first-line treatment. However, its efficacy in pemphigus is still to be established. It has been reported that rituximab is contraindicated when used in high doses of systemic corticosteroids. There are also various other options for Pemphigus Vulgaris Treatment, including immunoadsorption, specific plasmapheresis, and photodynamic therapy. Rituximab is being studied in a clinical trial. Researchers believe that the combination of rituximab and high-potency topical corticosteroids could be considered as an option for pemphigus treatment. In February 2021, Merck decided to acquire Pandion Therapeutics for almost $1.85 Billion for expansion of their autoimmune disease-targeting candidate’s portfolio. Pandion has been developing new therapeutics for addressing the unmet needs of patients suffering from autoimmune and inflammatory diseases
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